What is Moebius Syndrome?
Moebius syndrome is a rare congenital disorder involving paralysis of the sixth and seventh cranial nerves. It causes limited eye movement, lack of facial expression, esotropia, limb deformities, feeding difficulties, and sometimes intellectual disability. Between 300–2000 cases have been reported.
In addition to these features, Moebius syndrome may involve other cranial nerves and cause deformities of the mouth, tongue, and jaw. Children can experience swallowing problems, musculoskeletal abnormalities, and developmental challenges that require specialized medical care and support.
Why was your child born with a birth defect?
Help us look for answers. Enter your case in the
National Birth Defect Registry
“Because every birth defect has a cause.”
Fact Sheet Continues Below
How many children have Moebius Syndrome?
Moebius Syndrome is a very rare condition affecting boys and girls equally. There have been over 100 documented cases of this syndrome.
How do you know if your child has Moebius Syndrome?
Currently, there are no reliable prenatal tests for Moebuis Syndrome. Associated features like limb defects may be diagnosed through obstetrical ultrasound scans. The first signs of this syndrome in newborn infants can be impaired ability to suck, excessive drooling, crossed eyes, and other symptoms mentioned above.
What causes Moebius Syndrome?
Most cases of Moebius Syndrome occur randomly without any apparent cause. In some cases chromosomal abnormalities have been detected. The medical literature offers conflicting theories on the cause of the syndrome. Genetic counseling is available for affected families. Other anomalies have been associated with Moebius Syndrome including Poland’s Syndrome, Pierre Robin Syndrome, and other cranial nerve palsies.
How can you help a child with Moebius Syndrome?
There is no treatment for the underlying disorder. However, several things can be done to help children with Moebius Syndrome. Special tubes are available to help with feeding. Tubes can also be inserted in a child’s ears to reduce fluid and improve hearing. Surgery may be performed to correct crossed-eyes, repair cleft palates, and improve limb and facial deformities. Physical and speech therapy can improve motor skills and speech. Depending on your child’s needs, his medical team may need to include a pediatrician, a neurologist, an ENT (Ear Nose and Throat) specialist, an ophthalmologist, a physical therapist, and a speech therapist.
What’s in the future for a child with Moebius Syndrome?
Children with Moebius Syndrome may have speech problems and hearing loss and some may also experience learning difficulties. Mild retardation has been reported in 10-15% of the cases of Moebius Syndrome. Your child’s quality of life will depend on the severity of his/her symptoms.
Fact Sheet by:
Birth Defect Research Children, Inc.
www.birthdefects.org
